Jan. 24, 2007
A diet rich in omega-6 polyunsaturated fatty acids may be associated
with a higher risk of prostate cancer, and could explain why Jamaica has
the world's highest incidence of the disease, according to study
findings published in the January issue of the Journal of Urology.
Charles B. Brendler, M.D., of the University of Chicago, and colleagues
conducted a study of 148 men in Kingston, Jamaica, who were tested for
the presence of prostate-specific antigen. Biopsies were performed on
the 54 men with 2.6 ng/mL or more of the antigen, of whom 24 had
prostate cancer.
Erythrocyte membrane polyunsaturated fatty acid levels were also
analyzed, revealing a positive correlation between tumor volume and the
linoleic acid-to-docosahexaenoic acid (omega-3) ratio. There was also a
positive correlation between the tumor Gleason score and linoleic acid
levels.
The authors note that the Jamaican diet includes the widely consumed
ackee fruit, which is rich in omega-6 polyunsaturated fatty acid
linoleic acid, and also that the country's leading cause of death is
prostate cancer.
"The positive correlations between linoleic acid and Gleason score, and
the linoleic acid-to-docosahexaenoic acid ratio and tumor volume support
studies showing that omega-6 polyunsaturated fatty acids stimulate and
omega-3 polyunsaturated fatty acids inhibit prostate cancer growth,"
they conclude.
A diet rich in omega-6 polyunsaturated fatty acids may be associated
with a higher risk of prostate cancer, and could explain why Jamaica has
the world's highest incidence of the disease, according to study
findings published in the January issue of the Journal of Urology.
Charles B. Brendler, M.D., of the University of Chicago, and colleagues
conducted a study of 148 men in Kingston, Jamaica, who were tested for
the presence of prostate-specific antigen. Biopsies were performed on
the 54 men with 2.6 ng/mL or more of the antigen, of whom 24 had
prostate cancer.
Erythrocyte membrane polyunsaturated fatty acid levels were also
analyzed, revealing a positive correlation between tumor volume and the
linoleic acid-to-docosahexaenoic acid (omega-3) ratio. There was also a
positive correlation between the tumor Gleason score and linoleic acid
levels.
The authors note that the Jamaican diet includes the widely consumed
ackee fruit, which is rich in omega-6 polyunsaturated fatty acid
linoleic acid, and also that the country's leading cause of death is
prostate cancer.
"The positive correlations between linoleic acid and Gleason score, and
the linoleic acid-to-docosahexaenoic acid ratio and tumor volume support
studies showing that omega-6 polyunsaturated fatty acids stimulate and
omega-3 polyunsaturated fatty acids inhibit prostate cancer growth,"
they conclude.
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