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Paul Scholes, Ji-sung Park and Edwin van der Sar all face late fitness tests ahead of the United's opening Champions League clash against Celtic at Old Trafford.
Scholes and Park are both suffering from minor knocks, while van der Sar, who missed training on Tuesday, has a stomach bug.
"Ji picked up an injury against Spurs and has gone for a scan this afternoon," revealed Sir Alex.
"Paul suffered a dead leg in training on Sunday but still managed to do a bit of running to get the circulation going afterwards. I'm hopeful he'll be fit for the game and if he is he'll definitely start.
"Edwin has a stomach upset but I'm hopeful they'll all be okay for Wednesday."
Sir Alex also confirmed that Wayne Rooney will be in the Reds'starting eleven having completed a three-game domestic ban.
"It's very important to get Wayne back playing again," insisted the Reds' boss. "He, like Paul Scholes, hasn't had a lot of football recently and Wayne in particular needs to get back into action.
"He's got great energy and enthusiasm and he'll be keen to do well on Wednesday evening."
United go into their latest European campaign determined to make up for a series of increasingly underwhelming performances since their Champions League triumph in 1999.
Scholes and Park are both suffering from minor knocks, while van der Sar, who missed training on Tuesday, has a stomach bug.
"Ji picked up an injury against Spurs and has gone for a scan this afternoon," revealed Sir Alex.
"Paul suffered a dead leg in training on Sunday but still managed to do a bit of running to get the circulation going afterwards. I'm hopeful he'll be fit for the game and if he is he'll definitely start.
"Edwin has a stomach upset but I'm hopeful they'll all be okay for Wednesday."
Sir Alex also confirmed that Wayne Rooney will be in the Reds'starting eleven having completed a three-game domestic ban.
"It's very important to get Wayne back playing again," insisted the Reds' boss. "He, like Paul Scholes, hasn't had a lot of football recently and Wayne in particular needs to get back into action.
"He's got great energy and enthusiasm and he'll be keen to do well on Wednesday evening."
United go into their latest European campaign determined to make up for a series of increasingly underwhelming performances since their Champions League triumph in 1999.