Arsenal put on a magical display at the Emirates Stadium as they closed in on the Champions League knock-out stages.
Cesc Fabregas put the Gunners ahead on five minutes with a stunning strike before Alex Hleb's shot was deflected in by Slavia defender David Hubacek.
Theo Walcott got his first Champions League goal after a goalkeeping error before Hleb scored one and set up Walcott for his second.
Fabregas finished a fabulous move before Nicklas Bendtner wrapped it up.
It was a simply stunning display from Arsenal, who registered their best ever win in the Champions League.
Arsene Wenger rewarded Walcott for his eye-catching cameo at the weekend with a first Champions League start.
The 18-year-old, who started up front alongside Emmanuel Adebayor, had a quiet opening 20 minutes but his team-mates continued in the dazzling form they have shown all season.
Emmanuel Eboue's pace caused havoc down the right, Hleb was outstanding on the left while Fabregas pulled the strings in the middle.
Hleb's trickery took him to the byline and he cut the ball back for Fabregas to lift a perfectly-placed shot beyond Martin Vaniak as Arsenal took the lead inside five minutes.
Slavia fashioned virtually their only chance of the evening when David Kalivoda fired narrowly over the bar before Arsenal made it 2-0.
The visitors failed to clear a corner and Hleb's powerful strike took a deflection off Hubacek's outstretched leg and beat Vaniak.
Walcott's first telling contribution came after 28 minutes when he delivered an inviting cross for his strike partner, but Adebayor could only head straight at the keeper.
A little over 10 minutes later, he was celebrating his first Champions League goal.
Daniel Pudil played his keeper into trouble with an ambitious backpass and Vaniak's attempted clearance went straight to Walcott.
The teenager still had plenty to do though and he coolly sidestepped Vaniak before firing a precise shot in between two covering defenders.
Desperate Slavia coach Karel Jarolim made a change at the break but Arsenal's response was simply to find another gear.
Hleb got the goal his performance deserved from Fabregas' perfect pass and the Belarussian then set up Walcott, who raced down the left channel before finishing with the outside of his right foot.
It was a sumptuous finish but the best was yet to come.
Slavia could - and did - only stand and admire as Arsenal went from defence to attack in a flash, the ball gliding from Hleb to Adebayor and on to Walcott before the striker set up Fabregas to provide the gloss finish.
Arsenal were 6-0 up after just 58 minutes and Wenger, not surprisingly, made a triple change, introducing Gilberto, Nicklas Bendtner and Tomas Rosicky for Adebayor, Hleb and Mathieu Flamini.
The changes disrupted Arsenal's rhythm and brought welcome respite to the demoralised Slavia players.
They even had a chance when William Gallas' slip let in Stanislav Vlcek, but Manuel Almunia made a smart save.
Walcott came agonisingly close to a hat-trick but was denied from six yards by a fabulous save from Vaniak - before Rosicky fired the rebound against the bar.
Arsenal got their seventh when Bendtner played a one-two with Eboue, who backheeled his return for the Dane to poke the ball home at the second attempt.
Cesc Fabregas put the Gunners ahead on five minutes with a stunning strike before Alex Hleb's shot was deflected in by Slavia defender David Hubacek.
Theo Walcott got his first Champions League goal after a goalkeeping error before Hleb scored one and set up Walcott for his second.
Fabregas finished a fabulous move before Nicklas Bendtner wrapped it up.
It was a simply stunning display from Arsenal, who registered their best ever win in the Champions League.
Arsene Wenger rewarded Walcott for his eye-catching cameo at the weekend with a first Champions League start.
The 18-year-old, who started up front alongside Emmanuel Adebayor, had a quiet opening 20 minutes but his team-mates continued in the dazzling form they have shown all season.
Emmanuel Eboue's pace caused havoc down the right, Hleb was outstanding on the left while Fabregas pulled the strings in the middle.
Hleb's trickery took him to the byline and he cut the ball back for Fabregas to lift a perfectly-placed shot beyond Martin Vaniak as Arsenal took the lead inside five minutes.
Slavia fashioned virtually their only chance of the evening when David Kalivoda fired narrowly over the bar before Arsenal made it 2-0.
The visitors failed to clear a corner and Hleb's powerful strike took a deflection off Hubacek's outstretched leg and beat Vaniak.
Walcott's first telling contribution came after 28 minutes when he delivered an inviting cross for his strike partner, but Adebayor could only head straight at the keeper.
A little over 10 minutes later, he was celebrating his first Champions League goal.
Daniel Pudil played his keeper into trouble with an ambitious backpass and Vaniak's attempted clearance went straight to Walcott.
The teenager still had plenty to do though and he coolly sidestepped Vaniak before firing a precise shot in between two covering defenders.
Desperate Slavia coach Karel Jarolim made a change at the break but Arsenal's response was simply to find another gear.
Hleb got the goal his performance deserved from Fabregas' perfect pass and the Belarussian then set up Walcott, who raced down the left channel before finishing with the outside of his right foot.
It was a sumptuous finish but the best was yet to come.
Slavia could - and did - only stand and admire as Arsenal went from defence to attack in a flash, the ball gliding from Hleb to Adebayor and on to Walcott before the striker set up Fabregas to provide the gloss finish.
Arsenal were 6-0 up after just 58 minutes and Wenger, not surprisingly, made a triple change, introducing Gilberto, Nicklas Bendtner and Tomas Rosicky for Adebayor, Hleb and Mathieu Flamini.
The changes disrupted Arsenal's rhythm and brought welcome respite to the demoralised Slavia players.
They even had a chance when William Gallas' slip let in Stanislav Vlcek, but Manuel Almunia made a smart save.
Walcott came agonisingly close to a hat-trick but was denied from six yards by a fabulous save from Vaniak - before Rosicky fired the rebound against the bar.
Arsenal got their seventh when Bendtner played a one-two with Eboue, who backheeled his return for the Dane to poke the ball home at the second attempt.
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